Sentence examples for if slippage from inspiring English sources

Streisinger's seminal idea was that if slippage was to occur, then slippage in repetitive sequences would allow misaligned intermediates to form that could be stabilized by correct base pairing.

With that in mind, the ideal antimitotic agent should therefore be effective enough to prevent mitotic slippage, or even if slippage occurs, severe CIN that compromises tumor cell viability must be invoked by the single inhibitor or in combination with other drugs.

Moreover, if slippage-resistant HT29 colon cancer cells, which normally die in mitosis when treated with Taxol, are exposed to Cdk1 inhibitors during mitotic arrest, they survive concomitantly with reversal of Bcl-xL/Mcl-1 phosphorylation.

All of the differences between the sequenced alleles were caused by addition, removal and rearrangement of repeat units as expected if strand slippage and recombination are the predominant mechanisms that generate new alleles [1].

If polymerase slippage is the dominant force then we would expect to see a high degree of variability in repeat lengths and homogeneity between phylogenetic analysis carried out between sequence regions upstream and downstream of repeats [9], [35].

Next, we asked if mitotic slippage can promote establishment of OIS.

ArgI production may be also rescued in a similar manner if transcriptional slippage around the adenosine 9-mer corrects the internal frameshift.

If strand slippage did not occur after dNTP insertion opposite the template 5′-neighbor base, then a −1 deletion would result.

Levinson and Gutman [ 62] have proposed that if replication slippage is an important mechanism, a longer repeat would tend to show more variation, since the chance of replication errors is higher for a longer stretch of repeated sequence.

The OECD said the chancellor should allow in-built stabilising mechanisms to work to support demand even if this meant slippage in his plans.

"It serves as a reminder that the country does not have much room for any fiscal slippage if it is to keep its top credit rating".