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However, if present in excess it contaminates groundwater.
Also, the metal free siderophores, if present in excess inside the cytoplasm, can potentially quench the cytoplasmic iron or extract bound iron from the cytoplasmic proteins that can be detrimental to the cell.
Chl a and most intermediate molecules of the Chl a synthesis produce ROS under illumination if present in excess amounts [30], and it is therefore critical to accurately control the levels of these compounds.
Indeed, IL-18 is a bivalent cytokine which can promote local angiogenesis and immunotrophism at appropriate dose but conversely promote a cytotoxic and thus deleterious commitment of uNK cells if present in excess [5].
Metal ions are usually toxic if present in excess, mainly due to their reactivity with thiol compounds and the thiolate and imidazolium groups of cysteine and histidine residues, respectively.
As mentioned, cells also convert serine into glycine for ammonia detoxification (r16 or EM 6): although maintaining a high extracellular concentration could be beneficial, it may also lead to net ammonia formation if present in excess.
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For example, miRNAs, provided they are not otherwise preoccupied with gene silencing, might be utilized therapeutically as a general inhibitor to disrupt or, if present in sufficient excess, even completely block formation of various retroviruses dependent on RNA-mediated Gag assembly.
These results (Table 2 and Fig. 2C) suggest that SecTRAPs can provoke a cell death via a mechanism not necessarily involving direct interactions with the endogenous proteins of the thioredoxin system, but that the thioredoxin system or at least TrxR1 may possibly have some protective effect if present in large excess compared to the SecTRAP level.
If calcium was present in excess of bicarbonate, waters containing moderate levels of magnesium produced acid even in the presence of bicarbonate, due to the precipitation of calcium carbonate.
The success rate for catalysis is improved because of the normalization of the FBS Sav concentration present in each sample before catalysis: option A is normalized by the FBS determination and option B by the specific binding capacity of the applied beads if Sav is present in excess in the CFE.
This is an excellent observation showing how Hg is more easily incorporated into the compact tissue of linea aspera, if Hg is present in excess.
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