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This problem could become important for de novo structure prediction, for example if predicted HSE values are used as restraints.
Rare missense variants were considered to be contributory if predicted to be pathogenic, disease causing or damaging by in silico prediction programs (MutationTaster, PolyPhen-2, SIFT).
In the case of the 46Ti/43Sc production route, the amount of 46Sc was found to exceed the prediction by a factor of ~50, while no long-lived 46Sc, even if predicted, could be determined in the final eluate available from the 43Ca/43Sc route.
As if predicted by 1980s cyberpunk literature, it's a future where gritty street culture finds new uses – and misuses – for our increasingly pervasive technology.
But private clients would be perfectly satisfied if predicted market shares for rival brands came within four percentage points of the outcome.
Well, in a warming world, we expect, and are already observing, increases in warm, wet weather in place of snowfall, so the effect the authors find may be more important if predicted changes in Greenland's climate are realized.
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It might be different if predicting a risk of sudden death were a simpler task.
Yet if predicting the future is a hopeless endeavor, learning from the past is not.
Several months before Lee's own disappearance, he was asked to comment on that of his colleague, Gui, and he answered as if predicting his own final chapter.
Even if predicting where its power will be most felt is difficult, that it will have great power does not seem to be in dispute.
If predicting the probability of entering future states, as in CIFs, is the primary interest then multi-state models are preferred.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com