Moreover, the active site of the protein-modifying enzyme needs to access the target residue on the substrate; this situation could be made more likely if the substrate existed in a less compact state or if modification occurred prior to protein folding [ 15, 16].
If the modifications occur in a portion of the molecule that is critical to its solution properties, the seemingly small compromises made to produce the recombinant peptide could have unintended consequences.
What's more, over two-thirds of modifications occur outside of the program.
If such covalent modifications occur, however, it is difficult to envision how they are modulated by cell signaling.
If similar epigenetic modifications occur in regions typically devoid of heterochromatin marks, it is possible that the recruitment of heterochromatic proteins in or near these euchromatic regions containing protein-coding genes results in repressed transcription through heterochromatinization.
However, if these oxidative modifications occur in members of the Prx family their reduction can be mediated by sulfiredoxins (Srx) [ 32], which might represent an adaptive process of eukaryotic cells to cope with increased H2O2 levels [ 22, 23].
With multiple codon coverage, some modifications occur.
Our results, however, cannot discriminate if these modifications occurred at the programming stage or at the execution stage (upper and lower motorneurons).
Therefore our results suggest that, even if some modifications occurred directly in the presence of pain[ 11, 14], adaptation to low back pain and modifications of motor control strategies are not implemented spontaneously.
Additionally, we ran a one-way repeated measures ANOVA to assess if the performance differed between trials in which no modification, only causally relevant, only causally irrelevant or both types of modifications occurred.
Over time, some modifications occurred.
