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Results from the second step showed stronger evidence for genetic heterogeneity of residual variance if heterogeneous residual variances were allowed for in the first step, although more extensive comparisons could not be made based on restricted likelihood, e.g. comparison of models that assume different combinations of fixed effects on residual variance.
Lack of central enhancement is key to distinguish epidermal cysts from more sinister lesions such as neurogenic tumours or sarcomas, particularly if heterogeneous signal is present because of internal debris.
If heterogeneous differentiation was found in the obtained HCC tissue, differentiation grade was classified based on the lowest differentiated grade.
We annotated all our SNPS using Annovar [ 18] and analyzed if heterogeneous blocks occur in "non-functional" regions or in segmental duplications.
One way to examine this possibility is to see if heterogeneous blocks map mostly to known segmental duplications in the genome.
Our results demonstrated that if heterogeneous methylation was ignored, then the frequency of reported methylation events for RUNX3 would have been consistent with the literature.
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Furthermore, our data show that the cellular distribution pattern of RACK1 on melanocytes in tumors, i.e. homogenous if malignant and heterogeneous if benign, is constant throughout the whole lesion.
Further studies will determine if GAGE proteins are markers of cancer stem cells and if the heterogeneous expression of GAGE proteins in tumours is a consequence of GAGE expression being turned off as the cells develop towards a more committed phenotype.
In a sense, this shared catalogue of genes evolves as if vast heterogeneous masses of microbial life were one superorganism.
These issues can be overcome easily if a heterogeneous, rather than homogeneous, catalyst is employed.
Different models are needed if the heterogeneous range assignment is taken into consideration.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com