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We then assessed how the relationship between self-reported adherence and HIV acquisition differed between the TFV and placebo gel groups, an interaction effect that should exist if effectiveness increases with adherence.
These studies support the general use of sustainability labels but point to further questions to be answered if effectiveness is to be increased.
To understand possible knowledge gaps between evidence and practice, the aim of this paper is to investigate if effectiveness studies of the 11 practice-based implementation components can be identified in existing scientific literature.
Our discussion highlights our strategy to balance pragmatic and explanatory features into the study design, describes efforts to enhance site recruitment and participant adherence, and summarizes our broader goal of post study dissemination if effectiveness and cost-effectiveness are demonstrated, by preparing training and protocol manuals for use in housing facilities across the U.S.
Using a carefully stratified and well-parameterized deterministic model of HIV-1 transmission, our analyses suggest that PrEP could have a profound impact on the HIV-1 epidemic, if effectiveness is high (high levels of efficacy and adherence) and usage persists over a decade or more; that is over much of the typical duration of sexual activity of an individual.
If effectiveness and cost-effectiveness can be proven, implementation in the Dutch health care system should be considered.
Similar(38)
If waterboarding works, and if that effectiveness is sufficient justification for its use, then surely the threat of permanent physical harm or death would be even more effective, and even more justified.
Delays are problematic if a patient's health deteriorates during the delay, or if the effectiveness of treatment is compromised.
With swift, if brutal, effectiveness the police took control of stewarding in six of the biggest stadiums.
Now a new technique may be about to join this array of powerful tools, although it remains to be seen if its effectiveness will match its conceptual elegance.
It might also be prudent to revisit cancer vaccines to see if their effectiveness improves when used in combination with checkpoint inhibitors.
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