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These domains may have appeared on the list by chance, because a large gene family has more opportunities to be deleted if deletion events occur randomly.
Objective and Design to assess if deletion of the angiotensin-converting enzyme (ACE) gene is a risk factor for abdominal aortic aneurysms (AAAs) in normotensive patients.
If deletion seems too serious a step, then it is possible to deactivate an account which does not remove information but stores it in case you want to go back and start using the social network again.
Second, if deletion or nonsense mutation occurred on the dbpA or dbpB copy, no DbpA or DbpB, or only truncated versions would be detected on immunoblots.
Strains from the Keio knockout collection [51], [52] were used to examine if deletion of the depleted genes could increase the n-butanol tolerance of E. coli.
To further verify if deletion of SSN8 affects the general growth capability of C. neoformans, we carried out cell growth assays on different media (Materials and Methods S1).
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If deletions are more deleterious than insertions this suggests that the DI-ratio also correlates with functional constraint across the genome.
However, if deletions occur at high frequency in certain chromosomal sites in cancer merely as a consequence of the unstable nature of the chromatin domain, their appearance would not justify attributing tumor-suppressive function to the gene product.
However, the penalty is not severe if deletions and insertions constantly occur in the same locations.
If deletions in these sites occur, imprinting is lost and both alleles become expressed [ 55].
If deletions are eliminated by selection, populations that emerge in culture should carry more amplifications than deletions.
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