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Others also observed that p53 has an effect on HIF-1 α abundance only if artificially overexpressed or if concomitantly activated by DNA damage.
Thus, worms undergoing dietary restricttion do not live longer than control animals if concomitantly subjected to RNA interference (RNAi) against atg genes [ 72- 74].
Remission of synovitis of the knee after IAGC lasted longer, not only if concomitantly treated with methotrexate, but also with a procedure including general anaesthesia [ 22].
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Because PDE-5 inhibitors decrease degradation of cGMP, there is a risk of profound hypotension if administered concomitantly with riociguat.
Even if used concomitantly with ICS, adverse effects of LABAs are not necessarily a nonissue 48 and they should be stopped when possibile.
Oncoming evidence suggests that metabolic syndrome is a cluster of abnormalities that, if present concomitantly, increases the risk of developing both diabetes and subsequent cardiovascular complications.
However, the gastrointestinal side effects of orlistat may be reduced if taken concomitantly with natural fibres, such as Psyllium mucilloid (Cavaliere, Floriano, & Medeiros-Neto, 2001).
If applied concomitantly with population screening, vaccination would be associated with an ICER of I$200 to I$700 for each year of life saved depending on the baseline screening strategy employed.
These women were also randomized to hormone therapy if they were concomitantly enrolled in the WHI hormone trials [ 30, 31].
However, it is impossible to exclude that predictive value of HPV/p16 status can be diminished in HNSCC patients, if Rac1 is concomitantly expressed in HPV/p16-positive tumours.
Specifically, Beauséjour et al (2003) have shown that it is possible to revert cellular senescence following inactivation of p53, if p16 is concomitantly down-regulated.
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