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We next aimed to elucidate if ameliorated fibrosis observed upon Hydralazine treatment was due to its de-methylating efficacy.
As the degree of demyelination and/or axonal damage have been described as morphological correlates to increasing disability in MS and clinical severity of EAE [ 21], we undertook an effort to determine if ameliorated chronic EAE in Tie-2//TRE-claudin-1 C57BL/6 double transgenic mice was due to reduced CNS pathology.
Having established apparently opposing roles of endothelial and erythrocyte DARC with vascular DARC shuttling CCL2 but not CXCL1 across the blood brain barrier and erythrocyte DARC maintaining increased plasma levels of CXCL1 but not of CCL2, we finally asked if ameliorated EAE is due to the lack of endothelial or erythrocyte DARC.
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The present study was designed to examine the protective potential of lithium if any in ameliorating the alterations induced by aluminium (Al) on behavioral and neurochemical indices.
Pop-up retail -- and brand stores, for that matter -- can sound like gimmicks or stunts, but that can be ameliorated "if done in a tongue-in-cheek, appealing way that's not taken too seriously," said Matthew Glass, president of the event marketing and promotional agency for the Meow Mix Company, Grand Central Marketing in New York.
The world's most difficult problems would be greatly ameliorated if we were able to reduce population, and this notion should be discussed.
Judge Chin said that many of his concerns would be ameliorated if the parties came to this agreement.
That trench has some negative effects on the surrounding bay, which might be ameliorated if it were filled in during the construction of a runway, Mr. Zupan said.
Like most of the great Test batsmen before him, Root entered the Test arena with a technical flaw that must be ameliorated if he is fulfil his undoubted talent.
But without their prompting, conservatives might have been content to do very little or nothing about a series of shortcomings and failings that are amenable to at least being ameliorated, if not fixed.
Suicide will never be abolished – apart from anything else, you don't have to be clinically depressed to take your own life – but I have little doubt that the shocking statistics could be ameliorated if depression continued its journey out of the closet of fear and condemnation (including self-condemnation) and into the light of sympathy and understanding.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com