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These mice showed clearance of peripherin IF accumulations suggesting that gigaxonin gene transfer can reverse the pathology.
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If accumulation of wealth correlates with productivity then, in Graham's view, increasing variation of wealth might actually be a sign of good things.
If accumulation X and Y become compartmentalized during production, about 20%% of the GIIP will become bypassed.
To study if accumulation of supplemented fatty acids also differs between proximal EWAT and other depots, fresh adipose tissue explants were incubated in medium containing either radiolabeled oleic acid or radiolabeled docosahexaenoic acid (DHA).
If accumulation rates are high, then the deposits might develop transient pore pressures approaching lithostatic values.
Necrosis predominates during ischaemia if accumulation of metabolic waste and calcium is sufficient to induce osmotic swelling.
Further, the weak association between DNA damage and age found in this meta-analysis raises the question of if accumulation of damage is determinative for the aging process.
It might be important to periodically re-analyze a patient's genome, if accumulation of replication errors over a life time leads to increased heterogeneity.
If accumulation of 8-OHdG and somatic mtDNA mutations exceed a critical threshold, they can cause a biochemical defect in the mitochondrial respiratory chain and could result in a progressive decline of mitochondrial function [ 10, 34, 36].
In order to understand if accumulation of Myc protein induced by Rheb and S6K was regulated at the post-transcriptional level, we co-expressed Rheb and S6K together with an epitope HA-tagged form of Myc [ 10].
It would also be very useful to collect insonated and noninsonated tumors with the goal of assessing if accumulation of carriers is occurring (via extravasation) and perhaps perform microscopy work to validate the extravasation hypothesis.
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