The most significant association among specific molecular functions was with "DNA-binding transcription factor activity" (1.71E-25), known to be frequent among IDPs [ 3, 5, 14, 20].
For this work we analyzed slices from eight CP IDPs, L2005*A3, L2008G12, L2008R15, L2009*E6, L2009D11, L2009H9, L2011R11, and L2011*B6, provided to us by the Cosmic Dust Curatorial Facility at the NASA Johnson Space Center.
Electrostatic interactions have been shown to increase the "fly-casting" effect of IDPs [67].
Compared with the specific binding state, misbinding states may be less stable and as shown by Vavouri et al., the off-target binding is tightly regulated through the control of the concentration of IDPs [72].
Rather, such large values of apparent molecular mass can be attributed either to trimerization or to an extended conformation with low compactness of the polypeptide chain typical of IDPs [50].
The eastern Burmese border bore the largest burden of internally displaced people (IDPs) (4).
Of this number, an estimated 10.4 million were refugees and 15.6 million were IDPs (3).
A majority of countries did not mention IDPs (57%) compared with 48% for refugees in their HIV NSPs.
This figure included 26.4 million internally displaced persons (IDPs), 15.2 million refugees, 10.4 million under UNHCR's mandate, 4.8 million Palestinian refugees and 895,000 asylum seekers [ 1].
16, 22– 25 Single-molecule measurements avoid the signal averaging inherent in conventional ensemble studies and can therefore reveal hidden information in complex systems such as α-synuclein and other IDPs, 26, 27 which are in general prone to structural heterogeneity.
Bioinformatic analysis of proteins containing N-terminal ER signal peptides has identified only 10% of these proteins as IDPs (>70% disordered), suggesting that IDPs are under-represented in the secretome.
