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The available data suggest that Prod1, and thereby its role in encoding PD identity, is restricted to salamanders.
Meanwhile, an alignment of these two elements showed that their similarity (93.2% pairwise nucleotide identity) is restricted to the terminal regions (supplementary fig. S4 C and table S3, Supplementary Material online).
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By comparison with solution structures of other three-finger protein (TFP) superfamily, Garza-Garcia et al. [19] revealed that Prod1 and its role in encoding PD identity was restricted to salamanders.
Recent comparative analysis of the recombinant Prod1 3D solution structure to other known TFPs using phylogenetic techniques found that Prod1 was not a good match for any of the TFP families, including CD59 present in mammals [19], assuming that the role of Prod1 in encoding PD identity was restricted to the newt.
In both these clusters the high levels of identity are restricted to the transcribed regions with flanking DNA showing lower levels of similarity.
Consistent with this, when read identity was restricted to miRNAs by mapping back to known miRNA hairpin sequences, the length distribution of mappable reads was nearly identical between cells and exosomes.
Even if the identity theory is restricted to token-identity claims, however, there are still problems.
What it means to be from Pakistan – a country of 300 languages, diverse cultures, religions and identities – when real power is restricted to one province is a debate that has always raged in this country.
"So I was born a proud daughter of Pakistan," she writes, "though like all Swatis I thought of myself first as a Swati and Pashtun, before Pakistani". What it means to be from Pakistan – a country of 300 languages, diverse cultures, religions and identities – when real power is restricted to one province is a debate that has always raged in this country.
PICR, a web service allowing matching a large variety of protein sequence identifiers, is restricted to 100% identity matches and cannot discriminate the correct pair when recovering more than two identical sequences since it does not exploit information about genomic locations, contrarily to Corbank.
Expression of some of these genes is restricted to the dMGE thus endowing this region with its distinct identity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com