To identify this position more precisely, we computed the ratio of background positions to the total number of positions at a given distance as the false discovery rate (FDR).
We've previously identified this GOP position as the most cynical attack on the ACA of all — the Republicans choose to call it a "bailout" of insurers; actually, it's a way of keeping premiums for some plans from getting out of hand, until the industry has more experience dealing with its new clientele.
Site-specific analyses identified six consensus codons under positive selection, including 122β(GH5), indicating that the amino acid changes identified at this position may offer an adaptive advantage.
Indeed, positively charged (Arg and Lys), small uncharged (Ala, Gly, Ser) and hydrophobic (Leu, Met) residues were identified at this position [ 22].
The additional mutations identified at this position in β globins of pig, tree shrew and scaled reptiles raise the question about the importance of this codon for correct mRNA splicing.
Three polymorphisms have been identified at this position of exon 12 and coded as allele 1, 3 and 6 [ 20], i.e., allele 1: CTG AAAAATAC (deletion), allele 3: CTG AAGAAATAC and allele 6: CTG AAAAAATAC.
The mutation m.16023G>A occurs at position 1 in mt-tRNAPro (Fig. 2), and although to date, no other definitely pathogenic mutations have been identified at this position, m.8363G>A (mt-tRNALys) does occur at its cognate pair [Ozawa et al., 1997; Santorelli et al., 1996].
This also identified the position of scaffold on chromosome based on the genetic map provided in the supplementary information of Jia et al. [ 45].
This helps to identify the position more accurately.
