We identified this pathway in an unbiased genetic screen for mutations that either promote or suppress the neurpathological effects of the Aβ42 polypeptide on the Drosophila eye.
Huang et al. identified this pathway in liver cancer [ 65].
We do not know of any prior reports that identify this pathway in HER1 autocrine signaling.
Zhang et al. also identified this pathway [ 47]. (3) Lysine Degradation.
Array comparative genomic hybridization (aCGH) studies have identified this pathway as the most frequently altered in OC [17].
Nevertheless, the demonstrated role of COX/PG signaling in neoplasia identifies this pathway as an important anticancer target.
Zhang et al. used network-based bioinformatics methods to identify biomarkers for HCC and identified this pathway with 19 upregulated genes with a p value of 0.0016 [ 47].
Because most of these z-scores were relatively close to zero, it was difficult to identify this pathway by an analysis based on individual data sets.
The most fundamental challenge facing those who attempt to identify this pathway is the transient nature of the structures that form during endocytosis.
14, 15 PROPAGAPATH allowed us to identify this pathway for the first time in reconstructed skin, with a minimal number of steps when compared with the canonical myeloid differentiation primary response gene (88), nuclear factor kappa-light-chain-enhancer of activated B cells pathway.
