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Many computational tools for identifying strain modifications leading to targeted overproductions have been described in the literature.
Each isolate exhibited a different IGS sequence, demonstrating the utility of IGS sequences for identifying strain diversity (data not shown).
Aside from this strain, the two methods are in agreement with respect to the relative genome size estimates, identifying Strain A_03_34 as the smallest with increasing sizes through Strain B_04_28, Strain C_04_22, Strain D_04_27 and Strain E_01_37.
Since the use of binary variables is very common in metabolic network analysis for identifying strain improvement strategies [ 24, 25, 27], the reaction group concept will benefit the other applications as well.
We also characterized those strains with reduced cellular Chl contents in greater detail, identifying strain E2 as having a reduced PSII antenna size, improved photosynthetic activity and improved productivity in lab-scale fed-batch cultures, representing a promising starting point in the search for improved productivity outdoors.
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SID showed clear differences among S. cerevisiae populations in grape fermentation samples, identifying strains that are likely composing the populations and highlighting the impact of the inoculation of selected exogenous strains on natural strains.
Therefore, recent efforts have focused on identifying strain-specific or clinical-outcome-specific protein markers (Table 2).
This report is also the first to establish guidelines in defining and identifying strain-specific splicing across different mouse strains.
Previous efforts on comparative genomic analyses underscore the usefulness of CGH in resolving genetic lineages and identifying strain- or lineage-specific genes in L. monocytogenes [ 10, 19- 22].
Recently, another two H. pylori strains isolated from patients with gastric cancer 98-100) and from patients with gastric ulcer (B128) were sequenced and their 51 and 73 supercontigs, respectively, were compared for identifying strain-specific genes [ 35].
In addition, understanding the evolutionary events, which have led to contemporary sets of proteins can provide important insights into the functioning of contemporary regulatory networks, especially by identifying strain- and species-specific changes in TF complements.
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