Exact(4)
Magyar, C., Gromiha, M. M., Pujadas, G., Tusnady, G. E. & Simon, I. SRide: a server for identifying stabilizing residues in proteins.
Modeling: identifying stabilizing (shape-holding) and disruptive patterns and processes associated with bio-objectification. .
Modeling: identifying stabilizing (shape-holding) and disruptive patterns and processes associated with bio-objectification. (adapted from Holmberg et al. 2011).
Since a key objective of CMW deployment was to reduce maternal deaths by identifying, stabilizing and referring complicated births, a set of indicators will measure maternal perception of CMW's recognition of complications and subsequent care provided.
Similar(56)
It may simply reflect that it is harder to identify stabilizing interactions in proteins with intrinsically higher stability.
A pharmacologist can use this map to identify stabilizing mutations to develop new drugs.
The purpose of this work was to characterize and stabilize the fusion protein sEphB4 human serum albumin (HSA), a 120 kDa protein containing the extracellular domain of EphB4 and HSA, and to identify stabilizing excipients for storage.
A combination experimental approach, utilizing semi-empirical excipient screening followed by statistical modeling using design of experiments (DOE), was undertaken to identify stabilizing candidate formulations for a lyophilized live attenuated Flavivirus vaccine candidate.
This assay has the potential to guide protein engineering efforts and identify stabilizing conditions that may improve the chances of obtaining high-resolution structures of intrinsically unstable membrane proteins.
Based on these findings, future studies can prioritize work on these high expressing receptors and work to further optimize the construct and identify stabilizing ligands to assist with elucidation of the protein's three dimensional structure.
Several approaches have identified stabilizing molecules that also show a stimulatory effect on p53 DNA binding.
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