Unbiased proteomics analyses yielded new information about mechanisms activated in RDEB disease progression and identified processes related to tissue inflammation as significant contributors to disease manifestations.
GO analysis of the up-regulated genes identified processes related to metabolism, catabolism, transport, and the functions related to catalytic, transporter, hydrolase activities (Additional file 7: Figure S5, Additional file 8: Table S3).
Gene Ontology (GO) processes' enrichment presented in Additional file 1: Table S5 identified processes related to cellular macromolecule metabolism (P = 1.417E-10), and ubiquitination (P = 2.103E-08) pashways as being significantly enriched.
The chapter presents guidance for isolating and identifying process-related impurities and degradation products from pharmaceutical drug candidates using actual case studies.
The evaluation of hydrodynamic information associated with hydrochemical data has identified geochemical processes related to groundwater evolution, observed in regional flowpaths.
This approach helped identify common processes related to similar physiological states in leafy spurge crown buds and seeds.
Pathway analysis was employed to identify biological processes related to these miRNAs and their associated predicted mRNA targets.
The time period of 12 years has been chosen to be able to identify measurement processes related to drug management tools currently utilized and to see potential changes in the publications over time.
Functional annotation analysis of differentially regulated genes associated with AhR enrichment identified overrepresented processes related to fatty acid and lipid metabolism and transport, and xenobiotic metabolism, which are consistent with TCDD-elicited steatosis in the mouse liver.
We identified four processes related to the immune system in our work, with a high degree of significance (P value <1.3 E − 5 and FDR < 5.5 E − 3): immune system process, defense response, response to cytokine stimulus, and positive regulation of I κB kinase/NF- κB signaling.
Whilst the consortium quickly identified certain production and process related issues that were likely to arise during the operation of the project, other issues were felt to be more difficult to address.
