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Before this, although multi-perspective data have been integrated into HCC-related analyses [ 6- 8], no peer works providing global landscape of combinatorial gene regulatory network or identifying module classifiers for risk prediction has ever been reported in the specific context of venous metastasis of HBV-HCC.
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(ii) Identifying modules based on interactome mapping of DEG.
These results further indicate that the present approach for identifying modules yields modules that have biologically significant function [ 44].
The tool has been tested on experimental collections of human and yeast interactions, identifying modules that coordinate functionally related messages.
The method for identifying modules in CHD utilized shortest paths in the network between genes of interest [ 62].
We used a dynamic cut-tree algorithm for automatically and precisely identifying modules in hierarchical clustering dendrogram [ 43].
For example, let us take a look at GS03-BC05, an identified module significantly enriched by our GWAS findings.
The confusion matrix contains the number of overlapped nodes between the prescribed modules and the identified module.
The overlap between our identified module genes and those known oral cancer genes indicates that our identified modules are indeed related to the development of oral cancer.
Additional information concerns further pathways, processes, and interactions relevant to the identified module 'chemotaxis'chemotaxis
Another identified module is up-regulated with age and enriched for ' Cytolysis' [Fig. 2C].
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