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Using Illumina deep-sequencing, fetal aneuploidy was assayed, identifying Down, Edward, and Patau syndromes based on chromosome-specific trisomy [ 19].
These new tests are marketed for their effectiveness at identifying Down syndrome.
The first row in Table 2 shows the performance of the combined screening test for identifying Down syndrome and trisomy 18, followed by diagnostic testing in the women with the highest risk.
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As the first step in identifying down-regulated miRNAs in human melanoma, we identified significantly differentially expressed miRNA species in the melanoma cell line WM1552C (originally established from a stage 3 skin melanoma of a 72-year-old patient) compared to those in the normal melanocyte cell line HEM-l by hybridization of total RNA samples to miRNA probe arrays (see Methods).
Importantly, microdissection was found to be a better tissue processing technique than macrodissection for identifying down-regulated genes including potential tumor suppressor genes in gastric cancer.
The results show that the presence of cocaine in a liquid sample could be identified down to a concentration of 0.7 nM within one minute.
Tumours can be identified down to a few mm in diameter with MRI and to 4-5 mm for functional images with PET.
We also identified down-regulation of catalase, which has important antioxidant functions.
Equivalent calculations can also be performed to identify down-regulated genes.
Our study also identified down-regulation of cell cycle-related genes and significant reduction of apoptosis in Pten deficient medulloblastomas.
Although miR-206 is less abundant in the liver, our study identified down-regulation of miR-206 in the liver of SHP−/− mice.
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