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This broad-based approach will allow us to identify regions of genomic similarity and differentiation between interbreeding host races and closely-related species, thereby identifying divergent regions that may house "speciation genes", and testing current models of divergence with gene flow [ 49].
In particular, the final de novo assembly step is critical in identifying divergent sequences that may correspond to novel pathogens.
The General Health Questionnaire [ 17, 18] and Perinatal Grief Scale [ 19, 20] were most relevant in identifying divergent theoretical domains.
A virion-sense primer, specific for MX-P24, was designed by aligning curtovirus genome sequences and identifying divergent regions.
In order to maximize the probability of identifying divergent homologues, these tblastn searches were conducted using a very low stringency (E-value cutoff = 1000) with the low information filter turned off.
Such a program might appear inefficient in identifying divergent DIRS1-like retrotransposons because the training dataset that is currently available for these elements remains too limited (only 18 reference elements with detectable ITRs for example).
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However, as mentioned above, it is likely that some of the reported failures to identify Sec12 and Sec16 represent cases of extreme divergence, and in vivo analyses may well identify divergent orthologs of these proteins.
After adjusting for patient-level risk factors, a cross-validatory approach was adopted to identify "divergent" performance.
Previously, we reported that cytometry analysis of the local immune responses induced in mice dermally exposed to the respiratory sensitizer trimellitic anhydride (TMA 10%) and contact sensitizer dinitrochlorobenzene (DNCB 1%) could identify divergent expression of several immune parameters.
The purpose of this study was to characterize the inhibitor profile of acetylcholinesterases from Bm (BmAChE1) and Pp (PpAChE) compared to human and bovine AChE, in order to identify divergent pharmacology that might lead to selective inhibitors.
For example, J.P Guilford identified "divergent thinking" as a core feature of creative thinking which allows for production of out-of-the ordinary ideas [38].
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