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The framework we've offered above is also useful for identifying disruption opportunities or, if you're an existing intermediary, threats.
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In addition to identifying disruptions of terminal steps, we also identify complex disruption combinations in upstream pathways that indirectly negate the targeted output by propagating their action through the signaling cascades.
In light of recent clinical trials for CD47-blocking therapies in cancer treatment, these findings identify disruption of the CD47/SIRPα axis as a potential immunotherapeutic strategy for SCLC.
How can anyone identify disruption to the notoriously fickle climate of the UK? None of the extremes that we are told are now the norm are actually, well, extreme – unless you mean extremely quiet.
Today, few companies identify disruption as a threat.
This preliminary analysis might identify disruption of important interactions and improve our understanding about human diseases.
Specifically, we used the fluorescent dye DiOC6 in CGE-treated cells to identify disruption of mitochondrial membrane potential [ 3].
In our study we identified disruption in MAP3776c, the first gene in this genomic region led to depletion in the output.
Human heart biopsies and off-target screening has identified disruption of the mitochondrial architecture and an IC50 for AMP-kinase inhibition as low as 0.2 μM [ 18 ].
In three patients with type 2 changes, histology also identified disruption of the endplates as well as fatty degeneration of the adjacent bone marrow[ 4].
Respondents in the present study and in the study by Maibach et al. (2008) identified disruption of health care services (50%, 53% respectively) and increasing mental health conditions (53%, 41% respectively) as affected by climate change.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com