Feature-rich pharmacophores are useful for identifying compounds with high selectivity profiles.
This may be achieved by identifying compounds with enhanced potency for the inactivated state of Cav2.2.
Applicable of identifying compounds on novel targets when there is not enough training data available for these targets, and 2).
This was a first step in identifying compounds that may be involved in rhizosphere interactions and modulation of root colonization and endophytic establishment of bacteria.
Library comparison was performed by identifying compounds in the new library which are similar to compounds in an 'in-house' library.
Macrocyclic peptides designed to target this intermediate were synthesized with the goal of identifying compounds with specificity for this unique molecular target.
Ultimately, they screened more than 100,000 compounds with the antibody, first identifying compounds that could increase its binding to normal p53, then testing the successful compounds on mutant p53 in the test tube.
Even so, the identification of an LF target molecule represents the first step toward identifying compounds that can counteract the toxin--which could be a boon if the anthrax bacillus were to be used in a terrorist attack.
Compound ranking, or identifying compounds fulfilling a set of inclusion criteria, or elimination of poorly performing compounds can be based on algorithms combining several uptake, uptake rate or clearance measures and limits.
Application of these methods to assess both androgenic, estrogenic, and anti-steroidogenic properties of environmental contaminants in a single fish species will be a valuable tool for identifying compounds causing reproductive dysfunction in fishes.
We sought to deorphanize the EAG1 channel by identifying compounds that regulate the channel and bind to the CNBD.
