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How to cite this article: Hofree, M. et al. Challenges in identifying cancer genes by analysis of exome sequencing data.
CD133, a transmembrane glycoprotein, is probably the marker used most frequently in identifying cancer stem cells in NB5.
18F-FDG PET yields physiologic information that allows for identifying cancer based on altered tissue metabolism.
Circulating tumor-derived extracellular vesicles (EVs) have emerged as a promising source for identifying cancer biomarkers for early cancer detection.
This paper proposes an automatic classification system for identifying cancer related causes of death from death certificates.
By analyzing 6,038 samples across 24 different cancer types, we demonstrate that nCOP is highly effective in identifying cancer genes, including those with low mutation frequencies.
We conclude that germline variation across healthy human genomes provides a powerful means for characterizing somatic mutation frequency and identifying cancer driver genes.
Dr. Dulbecco went on to study breast cancer, pioneering a technique for identifying cancer cells by their genetic signature — the unique proteins displayed on their surface.
The algorithm is still used to analyze mammogram images, but rather than identifying cancer, it identifies whether patients are at greater risk for cancer, depending on the density of their breast tissue.
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The method was reasonably successful in identifying cancer-promoting mutations and determined the effects of specific mutations which could not otherwise be measured experimentally.
It is suggested that our way is more efficient in identifying cancer-related genes.
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