Sentence examples for identifying alterations in from inspiring English sources

The goal of this laboratory is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins and then translating these findings into important clinical tools.

Although research in this field is in its infancy, identifying alterations in the nucleus in neurodegenerative disease has potentially profound implications for elucidating the pathogenesis of these disorders.

Molecular markers identifying alterations in proliferation and apoptotic pathways could be particularly important in characterizing high-risk normal or pre-neoplastic tissue.

Although these studies are united in identifying alterations in fatty acid metabolism as a feature of RIFR strains, the precise implications for Mtb pathogenesis are unclear.

Comparing the polysomal mRNA levels with changes of steady-state levels allowed identifying alterations in polysomal occupancy, representing the ratio of polysomal mRNA levels to steady-state mRNA levels under the different conditions.

Here, we reasoned that identifying alterations in mRNA transcript levels in TS patient-derived cortical progenitors and developing neurons would help clarify, not only how calcium regulates gene expression in TS, but more broadly inform our understanding of the molecular mechanism of ASD.

Mapping altered metabolites to KEGG and SMPDB pathways identified alterations in immunomodulatory pathways including tryptophan catabolism and eicosanoid biosynthesis.

In this study, we used 2-DE to identify alterations in the protein expression profile of T-lymphocytes of PD patients.

Recently identified alterations in the function of specific genes in these cancers provide new potential therapeutic targets.

We identified alterations in DNA copy number and complex genomic rearrangements and demonstrated a low somatic point mutation frequency in the absence of tobacco mutagens.

We did not detect any mutations in JAK2, IFNGR1, and IFNGR2 within our 17 patient cohort, but identified alterations in other genes related to the antigen presentation and IFNγ machineries (e.g., STAT1, STAT2, TAP1, and TAP2), which were not restricted to progressing samples.