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Prone ventilation (PV) by means of prone positioning (PP) has been proposed as a strategy that may rescue the sickest patient from refractory hypoxemia [ 1, 3- 6], although identifying a survival benefit has proven difficult [ 4, 7- 12].
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In a previous meta-analysis, we identified a survival benefit from neoadjuvant chemotherapy or chemoradiotherapy before surgery in patients with resectable oesophageal carcinoma.
In addition, we identified a survival signature gene set that predicts overall patient survival.
Although overall the trial was unable to identify a survival benefit for tifacogin, this finding suggested that tifacogin might have greater efficacy among subgroups of patients.
The Whitehall studies of British civil servants identified a survival gradient across the occupational hierarchy that was closely correlated with SES [ 13].
Durham identified a survival rate of 15.2% in patients sustaining stab wounds compared to 7.3% in patients with gunshot wounds [ 29].
While these studies identified a survival mechanism for MM cells that persist after Bz treatment, they did not explain what cell cycle machinery components regulated the prolonged growth arrest and survival after Bz treatment.
We identified a meaningful survival gradient across quartiles of social vulnerability, and although women had better survival than men, survival for women with high social vulnerability was equivalent to that of men with low vulnerability.
It had the best statistical power when identifying a previously known survival-related pathway and the best averaged validation rate for LUAD and colon cancer.
We identify a compact survival predictor of seven genes for MCL patients.
Thus, to attempt to identify a meaningful survival effect we set a difference of 40% in mortality as our baseline desired effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com