This structure identified a loop from the α-subunit, originally named α-hook and recently reassigned and renamed αRIM, which directly binds AMP at CBS-3, suggesting that this loop functions as adenine nucleotide sensor.
Using 3C, Zhang et al. investigated all possible interactions between a prostate-specific enhancer and genes that are within an ~3 Mb window, identifying a single loop to a gene that is 1 Mb away from the enhancer [ 138].
In summary, we have described the structure of the earlier uncharacterized N-terminal portion of the talin head, revealing the domain boundaries and their architecture, as well as identifying a large loop in F1 that binds acidic phospholipids and is essential for integrin activation.
Our data reveal that expression of scb is induced by BMP signaling in the early embryo, identifying a positive feedback loop in which activation of scb allows integrin signaling, which further increases BMP responses at the dorsal midline.
Upon superposing the native drDDC structure onto the pig DDC structure (Fig. 4), we identified a flexible loop in drDDC structure, which did not superpose well.
In fact, Jodelka et al. (2010) [51] has recently identified a feedback loop in which low SMN levels exacerbate SMN2 exon 7 skipping.
The DAPK crystallographic structural studies [4] identified a basic loop that is not required for enzymatic activity [7], but has sequence homology to regions of other death protein kinases [4], [7], [9].
Our results identify a feedback loop in SMN expression by which low SMN protein levels exacerbate SMN exon 7 skipping, leading to a further reduction in SMN protein.
Kellermann et al. [ 76] identified a cerebelloparietal loop consisting of posterior parietal cortex (visual area V5, cerebellum) that facilitates predictions of dynamic perceptual events.
Another study [ 86] identified a regulatory loop between these microRNAs and ZEB transcription factors as well as the EMT inducer TGFβ.
