Quantitative high throughput chemical screens have been instrumental in identifying compounds that are active towards a variety of nuclear receptors.
Finding some predictions from ElemNet that match up to ICSD entries shows ElemNet is at least identifying compounds that are reasonable to assume to be stable.
This may be achieved by identifying compounds with enhanced potency for the inactivated state of Cav2.2.
Several successful macrophage-based screens were focused on identifying compounds that increase control of intracellular bacteria in vitro with the idea to use those compounds to boost effector immunity in vivo3,5.
Macrocyclic peptides designed to target this intermediate were synthesized with the goal of identifying compounds with specificity for this unique molecular target.
Feature-rich pharmacophores are useful for identifying compounds with high selectivity profiles.
Applicable of identifying compounds on novel targets when there is not enough training data available for these targets, and 2).
These well-tested methods range from cellular assays to some of the most up-to-date molecular approaches for identifying compounds that are active against viral enzymes and the development of viral resistance against drugs currently in use.
This was a first step in identifying compounds that may be involved in rhizosphere interactions and modulation of root colonization and endophytic establishment of bacteria.
Library comparison was performed by identifying compounds in the new library which are similar to compounds in an 'in-house' library.
Ultimately, they screened more than 100,000 compounds with the antibody, first identifying compounds that could increase its binding to normal p53, then testing the successful compounds on mutant p53 in the test tube.
