EGP goals were to identify polymorphisms in environmental response genes, study the functional implications of the polymorphisms, and associate them with various diseases in large population-based studies.
On the other hand, experimental assessment of the functional implications of all identified mutations is impractical.
The functional implications of the identified loci were not directly examined in these studies.
However, the functional implications of these changes identified by visual inspection are unclear; hence it is difficult for the clinician to ascribe significance to them.
To analyze the functional implications of the protein cohorts identified in this study, pTyr proteins that were differentially expressed in Hep3B and MHCC97H cells were subjected to PPI analysis.
The intronization of exons has been identified previously in retroposed genes of mammals (Szczesniak et al. 2011), but the functional implications of intronization are not yet known.
In order to elucidate the functional implications of alterations in the miRNA profile it is a widely accepted approach to identify the miRNA target genes by employing specific bioinformatics tools.
Hence in the analysis of the functional implications of the changes between isoforms we are limited to using proxies of function to identify potential changes.
In order to fully characterize the functional implications of the organized water molecules observed in the pore and their role in ion permeation, it is necessary to identify the monovalent ion binding sites in the GLIC structure.
