Sentence examples for identify longevity from inspiring English sources
Measuring the mutant gene lifespan, each missing one gene, is traditionally employed to identify longevity genes.
We will first discuss the efforts to identify longevity loci by genetics approaches.
In humans, both candidate gene and genome-wide genetic association approaches have been applied in an attempt to identify longevity loci.
However, the labor intensity of the life span assays and the interactions of multiple proteins during aging make it difficult to exhaustively identify longevity genes by traditional screening of single or double knock-out or knockdown mutants.
A main goal of the analysis was to identify longevity-associated genes with the highest level of support based on currently available microarray data.
As the main aim of JSS is to identify longevity-assurance genes, DNA samples to perform telomere length measurements were available from all JSS participants.
In the future, it would be important to identify longevity-defining cellular processes that are responsive to the observed in atg32Δ cells alterations in the repertoires of membrane lipids constituting mitochondria, the ER and the PM.
Yet Church noted that even identifying longevity genes is immensely difficult: "The problem is that the bowhead whale or the capuchin monkey or the naked mole rat, species that live a lot longer than their close relatives, aren't that close, genetically, to those relatives — a distance of tens of millions of genetic base pairs".
Notably, XBP-1 has been shown to function synergistically with DAF-16 to activate dox-1, a newly identified longevity gene, leading to enhanced resistance to ER stress and extended life span in daf-2 mutants (Henis-Korenblit et al., 2010).
Hence, the low contrast between cases and controls likely has reduced our probability of identifying longevity loci.
The newly identified longevity locus on chromosome 5q33.3 is located in an intergenic region on chromosome 5q33.3, 302 kb downstream of the EBF1 gene.
