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Fernandez-Recio et al. [ 22] apply docking simulations and analyze interaction energy landscapes to identify interface residues.
To identify interface residues that are important for CSP-2B binding to CED-3, we constructed a three-dimensional structural model of the CED-3/CSP-2 complex based on the crystal structure of active caspase-3 22.
Using a simple distance criterion to identify interface residues, we obtained a set of 2763 heterodimeric and 5846 homodimeric interfaces in structures that have a good coverage of the corresponding protein sequences.
In order to identify interface design requirements for this novel intervention, exploratory research using focus groups was therefore conducted with young people from the age categories most at risk of acquiring STIs.
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Based on this study, lower and upper alpha activities appear to be valid measures to identify interfaces that are best matched to computer tasks.
An integrated, normalized value (between 0 and 1) based on equivalent residue contacts (Q-score) is computed for every pair of subunit interactions and scores that are significantly above zero readily identify interfaces that are quasi-equivalent to each other.
67 Another method, based on a 3-D cluster analysis that evaluates residue conservation on a set of 35 protein families, can identify interfaces and functional residues.
Thus, we sought to identify interfaces of self-association for 5HT2c on cells, both to investigate their roles in receptor function and to aid us in engineering physiologically meaningful receptor species for structural analysis.
Additionally, this chapter addresses the challenges of creating seamless interfaces and establishes the methodology and tools for identifying interface issues that can arise among various functional groups.
We propose that the REST architectural style can be used with an identified interface design methodology to define an interface for telephony call control capable of being consumed by browser-based applications.
The formulation allows for a fully automated identification of the location of the initiation zone as well as automatic extraction of the local severity from the identified interface elements.
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