Futures Clinique is a participatory and exploratory futures workshop used to tackle uncertainties, identify disruptions and generate innovations [72].
This paper introduces, illustrates and evaluates the concept of Futures Clinique, which is a participatory and exploratory futures workshop and a collective futures research method to tackle uncertainties, identify disruptions and generate innovations.
This study aimed to identify disruptions in molecular pathways caused by the partial trisomy of mouse chromosome 16 (MMU16) harbored by Ts1Cje mice, which results in neuropathology similar to that observed in people with DS.
In our study we identified disruption in MAP3776c, the first gene in this genomic region led to depletion in the output.
Human heart biopsies and off-target screening has identified disruption of the mitochondrial architecture and an IC50 for AMP-kinase inhibition as low as 0.2 μM [ 18 ].
In three patients with type 2 changes, histology also identified disruption of the endplates as well as fatty degeneration of the adjacent bone marrow[ 4].
Respondents in the present study and in the study by Maibach et al. (2008) identified disruption of health care services (50%, 53% respectively) and increasing mental health conditions (53%, 41% respectively) as affected by climate change.
Within general practice, at the interface with community services and with hospitals, we identified disruption to traditional intraprofessional and interprofessional roles, assumptions, channels and media of communication which together created conditions that might compromise patient safety.
In addition to identifying disruptions of terminal steps, we also identify complex disruption combinations in upstream pathways that indirectly negate the targeted output by propagating their action through the signaling cascades.
