The evaluation of platelet antiaggregating profile lead us to identify a new potent prototype of antiplatelet derivative, that is (6a) (IC50=2.3 μM), which acts in arachidonic acid pathway probably by inhibition of platelet COX-1 enzyme.
For each clade identified, a representative prototype virus is listed to facilitate interpretation of the proposed numbering system (Table 2).
The evaluation of the activity against bloodstream trypomastigote forms of Trypanosoma cruzi forms lead us to identify a new potent trypamomicide prototype, that is, brazilizone A (4k), which present an IC50/24 h = 5.3 μM.
We also identify a novel family of esterases (prototyped by the previously uncharacterized N-terminal domain of Cas1p) that have a similar fold as the SGNH/GDSL esterases but differ from them in their conservation pattern.
The major components of the enhanced RCM process are identified and a prototype system is implemented as integrated with the various modules of the adopted CMMS (MAXIMO™).
Modbot founders Adam Ellison and Daniel Pizzata identified a problem in prototyping and building robots for use in manufacturing, research and basically any other application: parts were unnecessarily complicated and expensive, when in reality they could be much more affordable and much simpler, too.
That is, regardless the domain and the size of the input corpus, the prototype identified a similar proportion between different relations and extracted triples.
Examples of some of the markers used to identify each prototype include a Basal-Like cluster with highly expressed cytokeratin (KRT 5, 14, 17) and cell proliferation genes and low expression in genes associated with estrogen responsiveness and ERBB2.
In addition, the prototype evaluation identified a number of factors related to the physical and operational characteristics of the clinical environment that would affect uptake and long-term use of the device, most notably, the time required to obtain an image.
We suggest a strategy to identify diagnostic prototypes that are characterised by a limited number of parameters (symptoms, markers and other characteristics).
