The researchers identified a modification to the braincase that indicates the presence of a 'wulst' – a part of the brain unique to birds that assists in processing sensory input.
Attempts to identify a specific modification that can convert MyoD1 from an inactive to an active form have not succeeded.
Here, we identify a chromatin-modification module that underlies a recognizable form of ID, the Kleefstra syndrome phenotypic spectrum (KSS).
Importantly, our results identify a new chromatin modification associated with hypermutation and future studies will be required to next define functional roles in mechanisms of somatic hypermutation.
In the light of the difficulty to experimentally identify a discriminative receptor modification, our analysis points to the possibility of a systems-level regulation of endocytic sorting.
Recently, Wang et al. (2008) identified a histone modification module consisting of a combination of 17 modifications that are overrepresented at the promoters of genes that tend to be highly expressed in human CD4+ T cells (38).
In this paper we describe the post-mortem processing of the head and identify a range of modifications associated with the production of human skull-cups.
Here we describe the post-mortem processing of human heads at the Upper Palaeolithic site of Gough's Cave (Somerset, England) and identify a range of modifications associated with the production of skull-cups.
We identified a specific modification pattern, termed "bivalent domains," consisting of large regions of H3 lysine 27 methylation harboring smaller regions of H3 lysine 4 methylation.
On a grid of 1386 lat/long cells (landscape units, c. 30 km2) we used simple information on land cover and easily measurable landscape metrics to identify a gradient of landscape modification for the model region of Lower Saxony, Germany.
