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This method incorporates the genetic pathways into global AUC summary maximization and identifies survival associated pathways instead of individual genes.
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It is reasonable since the identified survival network is not merely a reflection of the survivalness in individual tumour types, but also incorporates all possible combinatorial factors between age, gender and tumour types.
To this end we first characterized 32 different mouse strains infected with P. berghei and identified survival as the best trait to discriminate between the strains.
The terms used to identify survival time data were: "survival", "Kaplan", "Cox", "life", and "time".
We also tested the significance of the identified survival network using a novel data randomisation procedure.
The life-cycle model identified survival conditions that favored the yearling smolt-migration tactic over the subyearling tactic.
The comprehensive phenotype description and an estimation of the survival rate of a subset of GEHA subjects were performed on this exceptional cohort to identify survival predictors [ 51].
To identify survival biomarker in PDAC and its potential mechanism related with cancer progression, we initially extracted survival correlated gene by Cox proportional hazards model from microarray dataset.
Eighteen cases were identified that identified survival of ≥3 years' duration from metastatic disease (12 American Joint Committee on Cancer [AJCC] Stage IV cases; six AJCC III cases) diagnosis.
In contrast, classification of the lymph node stations into 6 separate 'zones' identified survival differences based on the degree and location of zone involvement (Table 3).
How to incorporate biological pathways or functional groups into the model and identify survival associated gene pathways is still a challenging problem.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com