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We benchmark SGPA by examining two fundamental biological phenotypes: first, we explore glucose repression, in which SGPA identifies a requirement for the Mediator complex and a role for the CDK8/kinase module in regulating transcription.
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We identified a requirement for CAR in the terminal differentiation of glomerular podocytes and pronephric tubular epithelia.
Utilizing DCs derived from complement receptor 3-deficient miCR3−/R3−/− mice) identified a requirement for CR3 in the internalization of both sham- and serum-coated particles.
In this study we have identified a requirement for a DUB associated with the proteasomal 19S complex, POH1 (also known as Rpn11 or PSMD14), in the regulation of ErbB2 ubiquitination.
We thank Dr. Rohit Joshi for performing initial experiments that identified a requirement for InsP3R function in prothoracic gland cells and Rashmi Prasad for carrying out the combined Dilp2GAL4 DdcGAL4 rescue experiments.
We previously identified a requirement for dMCPH1 during early embryogenesis in Drosophila (Rickmyre et al., 2007).
We have identified a requirement for the direct activator BIM to convert oligomerized prepore BAK into a membrane-permeabilizing pore.
Genetic analysis has identified a requirement for bone morphogenetic factor (BMP), Wnt/β-catenin and nodal for this event [ 25].
You identify a requirement for LPA, and this led them to identify, by siRNA and ectopic expression, the G-protein coupled receptor LPAR2 as the critical receptor.
Interestingly, a recent report has identified a requirement for PKCδ in erbB2-driven proliferation of breast cancer cells [ 66], and erbB2 drives aberrant Ras pathway signaling.
Previous elegant studies performed in the fission yeast Schizosaccharomyces pombe have identified a requirement for heterochromatin protein 1 (HP1) for spindle pole formation and appropriate cell division.
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