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This report presents the first evidence that a member of the L1 family of nervous system cell-adhesion molecules is covalently modified by thioesterification with palmitate, and identifies a highly conserved cysteine in the predicted membrane-spanning domain as the site of modification.
Interestingly, using only sequences of different LGI family members to build the alignment, ConSurf identifies a highly conserved circular region in the top face of the β-propeller.
In addition, the computer program "exoniphy" [23] identifies a highly conserved exon sequence in the ADAR2 gene that coincides with the coding region of that R-domain in exon 0 in human, rat, mouse, dog, orangutan and horse.
Tie2 identifies a highly pro-angiogenic macrophage subset, Tie2-expressing macrophages (TEM).
Our work identifies a highly pro-inflammatory macromolecular structure composed of MPs and immune complexes abundant in RA synovial fluid.
However, the NPD study notably identifies a highly populated site that requires interaction with the open Cu sites (Cu⋯C 3.075 Å).
Similar(48)
Scientists at MIT's Whitehead Institute have identified a highly conserved network of noncoding RNAs acting in the mammalian brain.
Using bioinformatics and biophysics, we identified a highly conserved G4-prone sequence located in the stem-loop IIy' of the negative strand.
Beginning with an initial set of over five million blogs, we used social network analysis to identify a highly active 'Discussion Core' of over 11,000.
Our results identify a highly differentially expressed biomarker of priming, containing an EIF4-e domain, in uninfected individuals, as well as several other candidate genes.
Sequence analysis of Erg11p identified a highly conserved region typical of the cytochrome P450 class of mono-oxygenases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com