With the confidence scoring scheme disabled, SciMiner identified 1114 human gene identifiers of which 677 matched the gold standard set.
For M. davidii we imported 13,654 genes that could be assigned SWISS PROT identifiers, of which 37% were recognized.
For P. alecto we imported 12,188 genes that could be assigned to SWISS PROT identifiers of which 40% were recognized.
They reported 10 mosaic abnormalities in 9 offspring samples within the cleft dataset, the identifiers of which were provided upon request by the authors.
In order to respect the first principle of CHESS, it is imperative to generate unique canonical identifiers for each of these entities, according to a set of simple rules that will consistently result in reproducible, database-independent identifiers, some of which we outline here (Figure 3).
By clicking on a single matrix cell the user can access the list of source-specific sequence identifiers, each of which is, in turn, used to generate a cross-reference to the SolEST database itself as well as to the corresponding external database.
Once all output identifiers had been annotated in this manner, we calculated a score based on the number of input identifiers (In), the number of input identifiers for which at least one output identifier was returned (Hits), the total number of returned output identifiers (Out), and the number of preferred output identifiers (Matches).
The first figure in the parentheses indicates the ambiguity of these shared identifiers, i.e., the percentage of shared identifiers for which the corresponding structures in the two databases are different.
A number of studies focused on IP chemotherapy are currently ongoing (i.e., the GOG252, ClinicalTrials.gov identifier: NCT00951496; the PETROC, ClinicalTrials.gov identifier: NCT00993655; the iPOC, ClinicalTrials.gov identifier: NCT01506856), all of which have the advantage of maintaining a constant dose intensity.
"We have a bunch of identifiers, the names of which are indisputable and unique to Shakespeare.
Other PARP inhibitors are also under development, namely niraparib (ClinicalTrials.gov identifier: NCT01847274) and rucaparib (ClinicalTrials.gov identifier: NCT01891344), both of which are currently being tested in platinum-sensitive recurrence.
