"He's not only talented but extremely intelligent," says John Szarkowski, director emeritus of the Museum of Modern Art's photography department, "and, as we know, in our world intelligence often passes for wit - if you tell the truth, people think you are being funny, and in consequence he is one of the few photographers whose work is also identified by extraordinary wit".
All 129 miRNAs were assessed for allelic variability in a sample from the Ohio population (median = 10 strains per locus), which represents 83% of the miRNAs identified by de Wit et al. (2009) and 69% of the C. remanei miRNAs annotated in miRBase v20 (Kozomara and Griffiths-Jones 2011).
We included in our data set 20 miRNAs that were identified by de Wit et al. (2009) but that were not annotated in miRBase v20 (n = 20 for diversity within Ohio, n = 9 for interspecies divergence) because we sought to contrast the evolution of lineage-restricted versus phylogenetically preserved miRNAs.
This gene collection comprises a large majority of the miRNAs in the genome: 83% of miRNAs identified in de Wit et al. (2009) and 69% of miRBase release 20 miRNAs (Kozomara and Griffiths-Jones 2011) that include a recent update of Caenorhabditis miRNAs (Shi et al. 2013).
To wit, we identified six different student clusters, each featuring different behaviors and performance levels.
As the wit allele identified as an Smn enhancer, witd02492, is associated with a GAL4-responsive transposon, it seemed likely that it represented a gain-of-function mutation.
Among the identified modifiers was wishful thinking (wit), a type II BMP receptor, which was shown to alter the Smn NMJ phenotype.
It is noticeable that these gene clusters have properties similar to the LADs identified in human cells (de Wit and van Steensel 2009).
The subspecies B2 HAdV-14 (agent de Wit) was originally identified as an etiologic agent of acute respiratory disease in military recruits in the Netherlands during 1955 (5 ).
For the aggregate analyses described above, we included a set of candidate novel miRNAs identified through RNA-seq (de Wit et al. 2009) that are not currently deposited in miRBase release 20 (see Materials and Methods).
