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Other BRCA1 or BRCA2 variants identified were previously reported in dbSNP137.
Several of the genes identified were previously reported to be repressed (Supplementary Table 1) or induced (Supplementary Tables 2 and 3) by EWS FLI1, including p57/Kip2, NXK2.2, and DAX1-NR0B1.
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Interestingly, few of our identified biomarkers were previously reported.
A comparison with the NCBI dbSNP, with recently released SNP data from other groups and with in-house SNP data confirmed that >90% of the identified variants were previously reported SNPs that did not seem to explain BRC resistance of prolactinomas.
Fourty-nine abnormalidentifiedtified by MLPA were previously reported deletions and trisomy.
We identified proteins that were previously reported to be overexpressed in RA including metalloproteinase inhibitor 1 (TImyeloperoxidasexidase (MPO) and several S100 proteins.
A number of gonad-enhanced genes identified from our array were previously reported to be involved in gonad development and function.
All but three (B1R, B2R, and WR_148) of the 25 IgG binding proteins identified in our study were previously reported in IMV or EEV (Table 5), as measured by mass spectrometry [17] [20].
Several genes identified in RNA-Seq were previously reported to be associated with age-related diseases.
We identified four genes that were previously reported as drought-responsive in non-transgenic Andean potato cultivars.
Out of 44 receptors we identified by topology analysis, 21 were previously reported as psoriasis markers (they are listed in Table 3 with corresponding references).
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