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Nevertheless, for more fundamental conclusions of the biological impact of these kinases, a more detailed investigation is needed, e.g. by testing several independent shRNA sequences directed against the targets identified to rule out off-target effects.
Moreover, detailed analyses should include an assessment of the integrity of the meiosis-related genes identified, to rule out a recent accumulation of mutations rendering the genes non-functional (i.e., species-specific or even strain-specific loss of sex after isolation in culture).
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A need for a facility in DEMO has been identified to formulize rules and conditions for optional and conditional actions.
Also, the proper utility function and merging rules are identified to achieve the aggregate utility which can reflect comprehensive qualities of HESSs.
In general, "it is easier to identify an emergency than to rule one out" [ 8].
This was irrespective of whether CT was used to identify lung cancer or to rule out cancer.
However, specificity was almost 20 percentage points higher if CT was used to identify lung cancer than to rule out cancer (Table 2).
We were unable to identify periods with heavy workload to rule out whether this may have influenced validity.
Bowel symptoms are often considered an indication to perform colonoscopy to identify or rule out colorectal cancer or precancerous polyps.
Further studies are needed to identify or rule out other signaling pathways contributing to the myelin-induced cytokine expression.
A useful sepsis marker must not only help to identify or rule out sepsis, but it should also be able to be used to guide therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com