PPARγ is a ligand-activated transcription factor originally identified to play a key role in lipid homeostasis.
MicroRNAs (miRNAs), short non-coding RNA molecules of 19 25 nucleotides in length, were recently identified to play a key role in the regulation of gene expression.
A growing number of mammalian genes have been identified to play a key role in the cellular adaptive response to counter-regulate the renal hypoxia and the consequent process of fibrosis, among which is atrial natriuretic peptide (ANP).
Numerous microRNAs have been identified and elucidated to play a key role in cardiovascular diseases, as well as in neurological and autoimmune disorders.
In recent years, a distinct T-cell subset, termed Th17 cells, has also been identified and seems to play key roles in the activation of neutrophils and immunity to bacteria, particularly at mucosal surfaces.
As for commonly displayed plots of PCA loadings, gene relevence maps can help the user to interpret the embedding by identifying which genes are most important for different regions; for example, this can be particularly helpful for regions corresponding to transitions between different stages/groups as it can help to identify genes which play a key role for this transition.
Germany's Max Delbrück Center for Molecular Medicine (MDC) Berlin Buch and the Fu Wai Hospital of the Chinese Academy of Medical Sciences CAMSS) are building a new gene research laboratory in Beijing, the aim being to identify genes that play a key role in the pathogenesis of cardiovascular diseases.
We also identified key TFs, which appear to play a crucial role in the regulation of the flavonoid pathway in peach/nectarine acting to activate (MYB10, MYB123, bHLH3, WD40 and MYBPA1) or potentially repress (MYB16 and MYB111).
Among them, miR-290 and miR-302 clusters were identified in previous studies to play key roles in pluripotency maintenance.
