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The association was observed in subgroups of patients which were defined by their CFTR mutation genotype (all patients; subgroup I: no mutation detected; subgroup II: one CFTR allele identified to mutation class I, II or III; subgroup III: both CFTR alleles identified to mutation class I, II and/or III).
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The latter represent the majority of disease-linked mutations identified to date.
Among these mutants, we selected the one that exhibited the highest organic solvent tolerance and investigated the contributions of each identified mutation to organic solvent tolerance.
Therefore, it is difficult to tie-in the identified mutations to the pathogenesis of any primary form of human glaucoma.
In order to identify A to G mutation due to RNA-editing events, predicted A to I sites from http://rnaedit.com/download/ were translated to mm10 coordinates.
On the other hand, knowing that Mutation Test has a high application cost, another possibility is to try to identify mutations of some specific mutation operators, which an automatic static analyzer is not adequate to detect.
A pharmacologist can use this map to identify stabilizing mutations to develop new drugs.
We demonstrate the use of 'galign' to identify mutations leading to phenotypic consequences in C. elegans.
To identify mutations specific to SAMP strains, we performed whole exome sequencing of 6 SAMP and 3 SAMR strains.
We used PCR-based genotyping to identify a mutation in ABA INSENSITIVE2 (ABI2), positional information to identify mutations in AUXIN RESISTANT1 (and1) and ETHYLENE INSENSITIVE2 (EIN2), and whole genome sequencing to identify mutations in AUX1, AUXIN RESISTANT4 (and4), and ETHYLENE INSENSITIVE ROOT1/ PIN-FORMED2 (EIR1/PIN2).
The secondary aim was to identify somatic mutations amenable to currently available clinical and preclinical targeted therapeutic agents.
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