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A new compound 30 was identified to have improved biological activity.
A new lead structure, 15, was identified to have improved anti-proliferative activities in U937 cells, to induce apoptosis in U937, M12 and DU145 cancer cells, and to arrest U937 cells at the S-phase.
Though these analogues showed reduced potency against T. brucei cells, compounds NEU-1078 (81) and NEU-1090 (82) were identified to have improved cellular and biochemical selectivity profiles and are predicted to be CNS-penetrant.
Similar(57)
Recent advances in identifying DC subsets have improved the resolution of subset heterogeneity.
"We've looked at that game in detail, identified areas where we could have improved and we've got to take that forward now".
As these markets become increasingly competitive, firms that are more quickly able to identify and respond to market needs may have improved performance outcomes.
In the past, small or subtle lesions were difficult to identify but modern imaging techniques have improved their detection.
Including more items that capture factors identified in other studies could have improved the predictive power of our model.
Comparison of the results of a pretest with those of the posttest showed that students' ability to identify these moves had improved.
He said Facebook had "identified ways in which we should have improved".
The use of prescribed medication will have improved our ability to identify chronic asthma as this will identify those diagnosed and treated in primary care.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com