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Among the isoenzymes 3 families (CYP1, 2 and 3) have been identified to exert a pivotal role in drug metabolism and are concentrated in the liver and the intestine.
The ROR1 promoter was identified to exert high genetic background effects from a genome-wide association study of bipolar disorder [18].
Tepoxalin and licofelone (ML3000) have been identified to exert this function [ 45, 46].
A number of miR-218 targets have been identified to exert diverse functions in the brain.
In COX-2 promoter, numerous cis-elements are identified to exert transcriptional control of COX-2[ 22, 44].
Several miRNAs including miR-29a, miR-31, miR-103, and miR-107 have been identified to exert effects on the invasion of colon cancer cells in vitro and in vivo [ 15].
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The ethyl acetate extract of C. sappan heartwood was repeatedly extracted with CHCl3: MeOH and subjected to Sephadex and silica gel column chromatography to obtain a single final fraction, later identified to contain brazilin which exerted anti-RA effects in the mouse CIA model.
Two of the five sites identified to be under positive selection exerted minimal, if any, effect on functional changes from ECS to DAS.
Thus, it is highly desirable to conduct large-scale studies with adequate replication to identify variants that are likely to exert an effect on life span.
First, isolated C1q has been shown to exert immunosuppressive properties that have not been identified with C4 or C2.
Although rs13250873 and rs1556459 were not located in the gene regions, further replication of these findings and fine mapping of these loci are required to determine whether the identified polymorphisms exert their action through regulation of the nearby RAD21 and MGMT genes.
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