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Several genes and their protein products were identified to be regulated similarly across different PTM and gene expression levels (Fig. 3b,c).
To identify novel downstream genes affecting dauer formation, we used RNAi to screen candidate genes previously identified to be regulated by DAF-16.
In addition, we determined the expression of 153 non-MHC/non-NCR genes that were identified to be regulated in rat skin explant assays.
Importantly, several of the MHC and NKC genes that were identified to be regulated in the skin explant assays, including Aif1, Lst1, and Olr1, were also regulated in the GVHD affected skin of transplanted animals.
This data, taken together with the microarray data, indicates the commonalities of the spaceflight response in Salmonella in both LB and M9 media, and represents the first common genes that have been identified to be regulated by spaceflight and/or ground based spaceflight analogue culture in both rich and minimal media.
Transcription identified to be regulated more than 2.0log2 fold by RL + DC3000.
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However in a functional characterization study of the Eae18b congenic strain, Ccl11 was conclusively identified to be regulating many different disease pathways in this strain [ 30].
The first arthritis regulating QTL to be cloned and positioned to one polymorphism is the Pia4, which was identified to be regulating chronic inflammation by a non-synonymous SNV in the Ncf1 gene, altering the amino acid at position 153 [ 52].
Over 3,500 stromal genes were identified to be differentially regulated in DCIS compared to normal, whereas only 305 stromal genes were differentially regulated with the transition to invasion.
We used the Perl module GO: Termfinder [82] to assess overrepresentation of functional terms as defined by the gene ontology consortium [83], known RNA elements [44] and miRNAs [34], targetscan v3.0) among genes that were identified to be translationally regulated.
The reactions that were identified to be differentially regulated are summarized in Table 1.
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