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Germline mutations in a subgroup of those genes and other genes encoding signal transducers participating in the same pathway (HRAS, KRAS, NF1, SPRED1, BRAF, MEK1 and MEK2, alias MAP2K2) have been identified to be implicated in other clinically related disorders such as Costello syndrome ore neurofibromatosis type 1 [16].
In chickens, many independent studies reported that multiple genomic segments containing this gene were identified to be implicated in both egg weight and body weight [ 1, 3, 16, 19, 20, 53].
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Given that PT cases constitute a substantial proportion of all knee OA cases, any genetic risk factors identified are likely to be implicated in both types of patients.
A total of 60 unique domains were identified to be present in the proteins implicated in T2D.
The 35-kDa antigen was previously identified to be upregulated upon exposure to vancomycin, implicating a role for this determinant in resistance to cell envelope stress [25].
The proposed network obtained in the comparison between samples from patients in remission and control samples identified four miRNAs likely to be implicated in the relapses (hsa-miR-148a, hsa-miR-184, hsa-miR-193a and hsa-miR-96).
In addition, we reviewed the literature to determine if any of the identified genes were reported to be implicated in AD biology.
The novel findings reported here suggest that autoantibodies in BC sera are promising probes to identify centrosome proteins likely to be implicated in both autoimmunity and cancer.
In conclusion, this large whole-exome-sequencing study for LDL-C identified a gene not known to be implicated in LDL-C and provides unique insight into the design and analysis of similar experiments.
In the past few years, researchers have identified specific genes that appear to be implicated in dyslexia.
An alternative approach is to use a rare monogenic disorder or an animal model as an entry point, and, from an understanding of the biological pathways involved, identify other genes that are likely to be implicated, as was done by Vernes et al. (2008) in the case of developmental language disorders.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com