Exact(3)
The R225W variant, which is found in the second CBS domain (Figure 1), was identified to be functionally damaging by both programs.
Several of these genes have been identified to be functionally involved in developmental control, such as APETALA in identity with the Arabidopsis flower [ 53], and AINTEGUMENTA and AINTEGUMENTALIKE6 in flower patterning [ 54], PUCHI affecting root morphogenesis [ 55].
We expect that more proteins from our list might be identified to be functionally associated with Dhh1 in other genetic screens (e.g., overexpressing or deletion mutants), since many proteins that regulate PB/SG function do not have well characterized RNA metabolism or translational regulatory activities (Buchan et al. 2013; Yang et al. 2014).
Similar(57)
Despite its economic importance, only few genes have been functionally identified to be associated with endosperm chalkiness.
Inducible expression pattern of seven N. vitripennis AMP genes were verified, and two representative peptides were synthesized and functionally identified to be antibacterial.
In this study, the authors examined the distributions both of retrogradely labeled cells and of anterogradely labeled synaptic boutons following injections of tracers into subregions of cat area 17 functionally identified to be strongly dominated by one or other eye.
The four resulting insect-mammalian chimeras were all expressed functionally and identified to be TTX-sensitive VGSCs.
It seems interesting to note that the species-specific repeats thus identified appear to be functionally variable in different genomes: in some genomes, they are mostly associated with duplicated protein-coding genes, whereas in some other genomes with rRNA and tRNA genes.
Taken together with the bioinformatics data, these results indicate that a large proportion of the NKX2-5-binding regions in the embryonic heart that we have identified are likely to be functionally relevant and associated with cardiac development or function in vivo.
Nine diploid specific DOX resistance genes were identified and appear to be functionally interrelated as numerous genetic and proteomic interactions have been documented for these genes (Fig. 4A).
Additionally, to further narrow down the number of identified TFBS, we asked whether the identified TFBS are likely to be functionally relevant for adaptations in expression of RPS19 protein in the context of DBA/TEC.
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