For example, the focal adhesion pathway and the ECM receptor interaction pathway were identified to be the functional gene sets that were significantly differentially expressed in leukemia [20].
Hd1 and Ehd1 are key flowering time regulatory genes in rice; however, both genes have been identified to be non-functional in a Taiwan rice cultivar, Taichung 65 (T65), which shows little or no sensitivity to photoperiods (Doi et al. 2004).
Isolation procedure has been identified to be critical for functional analysis of cardiac mitochondria (Fannin et al., 1999).
As shown in Table 3 and Figure 3, 5 SDPs were identified to be highly relevant to functional specificity.
Arg-Gly-Asp-serine (Ser) sequences have been identified to constitute functional sites for fibronectin, the cell adhesion molecule [ 34].
In H. irregulare, 24 putative class I hydrophobin encoding gene sequences were identified, 16 appeared to be functional proteins whereas 8 were probable pseudogenes.
The T. reesei orthologue of the A. nidulans creB gene, designated cre2, was identified and shown to be functional through heterologous complementation of a creB mutation in A. nidulans.
Because our study analyzes species at greater phylogenetic separations, we are able to refine this approach to identify specific locations likely to be functional.
To investigate whether the identified PSWs are functional, we examined whether the tested windows overlapped with Ensembl-annotated genes.
