Sentence examples for identified to activate from inspiring English sources

Many of the drugs identified to activate either wild-type or mutant p53 function arose from screening protocols using p53 sequence-specific binding and consequent reporter activation [19].

For example, ESAT6, an antigen that is secreted by Mtb and inducer of macrophage apoptosis, was recently identified to activate the ER stress pathway [45].

Lysophosphatidic acid was the first agonist identified to activate Rho.

37 LPA was the first agonist identified to activate Rho.

5-Aminoimidazole-4-carboxamide riboside (AICAR) was the first compound identified to activate AMPK.

IL-17B was recently identified to activate both TNF and NFkB pathways [ 25].

For a given TF identified to be activated, we describe the algorithm as following.

Additionally, the P63- Irf6 signaling pathway has been identified to be activated by canonical Wnt signaling, which was associated with the growth and fusion of facial processes growth and fusion [ 51].

In the enriched pathway analysis, some common and cell-type specific signaling pathways were identified to be activated in PVCs and MRCs during osmotic stress (Fig.  10; Additional file 10).

Interestingly, both elements contain the ACGT core sequence, which once mutated (AAC CTCGG and GCA GCTGGA G) prevented the identified TFs to activate transcription in yeast, indicating its preponderant role in these interactions.

A central problem in this area is therefore to identify strategies to activate CREB-dependent gene transcription in macrophages.