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Early structural studies identified the involvement of the multiple Ig domains of NCAM and L1 in trans binding (Bateman et al., 1996; De Angelis et al., 1999; Jensen et al., 1999).
In a separate study, our group identified the involvement of a novel player, PKR, in the insulin signaling network of HepG2 cells [3].
Yeast display mutagenesis of rEDIII also identified the involvement of K310, but they did not examine the effect of substitutions at P364 for either 1A1D-2 or 9D12 binding [22].
After we identified the involvement of several brain areas in the MI task, we conducted a psychophysiological interaction (PPI) analysis [21] to examine the covariation between the neural activities in two brain areas.
We also identified the involvement of Axud1, MCl1, Tiparp and Txnip in the PDGF-PDGFR system as previously identified by Chen et al. [21] using a microarray-coupled gene-trap mutagenesis method.
In the present investigation, we identified the involvement of Sphk-1 in the induction of β-defensin 2 in human gingival epithelial cells (HGECs) and also found that the inhibition of kinase glycogen synthase kinase-3β (GSK3-β) augments HBD-2, all of which may have therapeutic application.
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To our knowledge, this is the first report identifying the involvement of an aquaporin in lens biomechanics.
Thus, it might be difficult to identify the involvement of specific species in brain injury after ischemia/reperfusion because [3H]hydromethidine is oxidized by ROS such as O2 · −, OH · −, or ONOO−.
These data identify the involvement of caspase-like activity in both aging and cell death in K. brevis and identify novel executioner enzymes and downstream targets that may be important for bloom termination.
Although we were able to identify the involvement of the AKP/MAPK pathway in JCV-mediated motility in colon cancer cells, our study did not address the specific roles of individual signaling molecules in these pathways.
First, we analyzed Arabidopsis microarray data to help identify the involvement of the WRKY TFs in jasmonate signaling.
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